Latest
27
Apr
Entry #018: Top supplements for longevity and ahtletic performance
The traditional demarcation between performance enhancement and longevity medicine is dissolving. Emerging data from 2024 and 2025 indicate that the
7 min read
25
Apr
Introducing the Calculator Library: 29 Peer-Reviewed Tools, One Transparent Workbench
The Scientist's Notebook is releasing what I believe is the largest free, source-cited collection of endurance calculators on
6 min read
24
Apr
Snippet #015: Gut Microbiota Adapt to Metabolize Systemic Lactate During Endurance Efforts
Current research identifies the intestinal microbiome as a responsive metabolic organ rather than a static passenger during physical exertion. During
2 min read
20
Apr
Entry #017: Autonomic Regulation and HRV-Guided Training Architecture
The quantification of recovery remains the most elusive variable in endurance periodization. While external load—measured in watts or pace—
7 min read
17
Apr
Snippet #014: Autonomic Competition at the Sinoatrial Node Drives HRV
The Mechanism
Heart rate variability (HRV) emerges from the dynamic interplay between sympathetic and parasympathetic signaling at the sinoatrial node,
2 min read
15
Apr
OpenLab #004: Competing at at an Ironman with Type 1 diabetes - Lucas (coachee) - Part II
Welcome back to the second part of OpenLab #004. In Part I, we covered the foundational physiology of glucose regulation
7 min read
13
Apr
Entry #016: The Science Of Training Periodization in Endurance Sports (Base, Build, Peak, Taper, Transition)
The fundamental challenge in endurance training architecture is managing the non-linear dose-response relationship between training stress and physiological adaptation. While
8 min read
10
Apr
Snippet #013: Sodium Bicarbonate Facilitates Hydrogen Ion Efflux to Preserve Contractile Function
During intense exertion, hydrogen ions accumulate within muscle fibers, creating an acidic environment that inhibits the enzymes responsible for energy
2 min read
08
Apr
OpenLab #005: Perceived Effort, Confidence & the Central Governor with Lex
In cycling, the cessation of effort rarely stems from catastrophic muscular failure. Instead, performance limits are frequently dictated by the
11 min read
06
Apr
Entry #015: The Physiological Necessity of Time Near VO2max (T@VO2max)
In the architecture of endurance performance, a fundamental tension exists between the accumulation of low-intensity volume and the precise application
8 min read